Núcleo de Estudos de Doenças Auto-imunes

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Development and use of touch-screen computer – assisted self interviewing in Portuguese Patients with Chronic Immune Diseases: Evaluation of an Electronic Version of SF 36V2

2016-07-09T09:33:57+01:00 2010-10-22|Categories: Artigos Originais e de Revisão|Tags: , , , |

Claudia Ribeiro*, Luis Moreira**,Augusta Silveira***, Isabel Silva****, Juan Gestal*****, Carlos Vasconcelos****** Abstract Aim:The major purpose of this study was to evaluate alternative automated methods of collecting data on health related quality of life (HR-QoL). In order to achieve this, we developed a study with the following objectives: (1) to evaluated the feasibility of electronic version in [...]

Disease-specific definitions of vitamin D deficiency need to be established in autoimmune and non-autoimmune chronic diseases: a retrospective comparison of three chronic diseases

2016-10-16T12:02:16+01:00 2010-10-14|Categories: Lúpus Sistémico Eritematoso|

Arthritis Research & Therapy 2010, 12:R191 doi:10.1186/ar3161 Anna R Broder (abroder@montefiore.org) Jonathan N Tobin (JNTobin@CDNetwork.org) Chaim Putterman (chaim.putterman@einstein.yu.edu) Abstract: Introduction: We compared the odds of vitamin D deficiency in three chronic diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and type 2 diabetes (T2DM), adjusting for medications, demographics, and laboratory parameters, common to all three diseases. We also designed multivariate models [...]

Rituximab inhibits structural joint damage in patients with rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitor therapies

2016-10-16T12:02:16+01:00 2010-10-9|Categories: Artrite Reumatóide|

Keystone, E, Emery, P, Peterfy, C G, Tak, P P, Cohen, S, Genovese, M C, Dougados, M, Burmester, G R, Greenwald, M, Kvien, T K, Williams, S, Hagerty, D, Cravets, M W, Shaw, T Rituximab inhibits structural joint damage in patients with rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitor therapies Objective: To [...]

The Belgian MIRA (MabThera In Rheumatoid Arthritis) registry: clues for the optimization of rituximab treatment strategies

2016-07-13T09:00:30+01:00 2010-10-9|Categories: Artrite Reumatóide|

Bert Vander Cruyssen (Bert.VanderCruyssen@Ugent.be) Patrick Durez (Patrick.Durez@ruma.ucl.ac.be) Rene Westhovens (Rene.westhovens@uz.kuleuven.ac.be) Marie-Joelle Kaiser (Mjkaiser@chu.ulg.ac.be) Ilse Hoffman (Ilse.Hoffman@skynet.be) Filip De Keyser (Filip.Dekeyser@Ugent.be) The MIRA Study Group (not@valid.com) Abstract Introduction: This study describes the results of the Belgian “MabThera In Rheumatoid Arthritis (MIRA)” registry: effectiveness, safety and evaluation of the current retreatment practice on the background of the Belgian reimbursement criteria for rituximab. Methods: All Belgian rheumatologists [...]

Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression

2016-10-16T12:02:16+01:00 2010-10-7|Categories: Artrite Reumatóide|

Leigh D Church (L.D.Church@bham.ac.uk) Andrew D Filer (A.D.Filer@bham.ac.uk) Esther Hidalgo (Hidalgoester@gmail.com) Katherine A Howlett (K.A.Howlett@bham.ac.uk) Andrew MC Thomas (Andrew.Thomas@roh.nhs.uk) Stephen Rapecki (Stephen.Rapecki@ucb.com) Dagmar Scheel-Toellner (D.Scheel@bham.ac.uk) Christopher D Buckley (C.D.Buckley@bham.ac.uk) Karim Raza (k.raza@bham.ac.uk) Abstract: Introduction. Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to systematically analyse the phenotype, cytokine profile and frequency of interleukin-17 (IL-17) producing CD4-positive [...]

Rheumatoid arthritis patients receive less frequent acute reperfusion and secondary prevention therapy after myocardial infarction compared to the general population

2016-07-13T08:57:09+01:00 2010-10-7|Categories: Artrite Reumatóide|

Sharon Van Doornum (svd@unimelb.edu.au) Caroline Brand (caroline.brand@mh.org.au) Vijaya Sundararajan (vijaya.sundararajan@med.monash.edu.au) Andrew E Ajani (andrew.ajani@mh.org.au) Ian P Wicks (ian.wicks@mh.org.au) Abstract Introduction: The 30-day case fatality rate after acute myocardial infarction (MI) for rheumatoid arthritis (RA) patients is twice that of the general population. This study compared the frequency and timeliness of early reperfusion therapy and treatment with secondary prevention medications after acute MI in [...]

Effect of etanercept in polymyalgia rheumatica: a randomized controlled trial

2016-07-13T08:59:08+01:00 2010-9-20|Categories: Artrite Reumatóide|

Arthritis Research & Therapy Frederik Kreiner (frederik.kreiner@me.com) Henrik Galbo (hga@sund.ku.dk) Abstract Introduction: To elucidate in polymyalgia rheumatica (PMR) the role of tumor necrosis factor (TNF) α and the therapeutic potential of blockade with soluble TNF-α receptor, we carried out the first randomized controlled trial with etanercept in PMR. Methods: Twenty newly diagnosed, glucocorticoid (GC) naïve patients with PMR and 20 [...]

Novo tratamento para a artrite reumatóide mostra-se eficaz

2016-10-16T12:02:16+01:00 2010-7-9|Categories: Artrite Reumatóide|

O abatacept, um membro de uma nova classe de fármacos que bloqueiam a acção das células do sistema imune, os linfócitos T, que estão envolvidos no processo inflamatório das articulações, mostrou-se eficaz no tratamento da artrite reumatóide. É esta a conclusão de uma nova revisão sobre a actuação deste fármaco efectuada pela Cochrane Collaboration, uma organização [...]

Doença de Behçet – manifestações clínicas de 12 doentes de uma Unidade de Doenças Auto-imunes

2016-07-09T09:36:10+01:00 2010-6-1|Categories: Artigos Originais e de Revisão|Tags: , , , , , |

Behçet Disease – Clinical manifestations of 12 patients of an Autoimmune Disease Unit Cláudia Costa, Rui Castanheira, Fátima Coelho, Carlos Dias Resumo Os autores apresentam um estudo retrospectivo de 12 doentes com doença de Behçet (DB). Todos os doentes cumpriam os critérios de diagnóstico de DB (International Study Group for BD, 1990). Todos os doentes eram Portugueses e [...]