Núcleo de Estudos de Doenças Auto-imunes

Sociedade Portuguesa de Medicina Interna
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Recommended immunization schedules for adults: Clinical practice guidelines by EVASG, EUGMS, WAidid

2016-10-16T12:02:12+01:00 2016-6-15|Categories: Divulgação|

WAidid suggests the reading of the first European guidelines on adult and elderly vaccinations just published 'Recommended immunization schedules for adults: Clinical practice guidelines by the Escmid Vaccine Study Group (EVASG), European Geriatric Medicine Society (EUGMS) and the World Association for Infectious Diseases and Immunological Disorders (WAidid)'. Diphtheria, tetanus, pertussis, influenza, pneumococcal disease, herpes zoster are among [...]

Health Reform on the Campaign Trail: The Policy & Practice Podcast

2016-10-16T12:02:12+01:00 2014-12-1|Categories: Divulgação|

Medicare and Medicaid have been the talk of the nation since Republican presidential hopeful Mitt Romney named Rep. Paul Ryan (R-Wisc.) as his running mate. Rep. Ryan became a key leader of the Republican party when he proposed his Path to Prosperity, a GOP-supported budget plan. His plan also provided alternative reforms to those in the Affordable Care Act. For example, the plan includes turning [...]

2013 Classification Criteria for Systemic Sclerosis

2016-07-09T08:36:34+01:00 2013-11-1|Categories: Divulgação|

An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative This criteria set has been approved by the American College of Rheumatology (ACR) Board of Directors and the European League Against Rheumatism (EULAR) Executive Committee. This signifies that the criteria set has been quantitatively validated using patient data, and it has undergone validation based on an external data set. [...]

Doença de Pompe

2016-10-16T12:02:13+01:00 2013-5-20|Categories: Divulgação|Tags: , |

O que é a Doença de Pompe? A doença de Pompe é uma doença lisossomal de sobrecarga causada pela atividade insuficiente do ácido á-glucosidase.1 Esta enzima lisossómica é responsável pela degradação do glicogénio intralisossómico, o qual representa apenas uma pequena percentagem (1-3%) do glicogénio celular total. A deficiência enzimática resulta numa acumulação de glicogénio lisossomal em múltiplas [...]

A comparative proteomic study of sera in paediatric systemic lupus erythematosus patients and in healthy controls using MALDI-TOF-TOF and LC MS-A pilot study

2016-10-16T12:02:13+01:00 2012-12-1|Categories: Divulgação|Tags: , |

Background Paediatric systemic lupus erythematosus (pSLE) exhibits an aggressive clinical phenotype with severe complications and overall poor prognosis. The aim of this study was to analyse differential expression of low molecular weight (LMW) serum protein molecules of pSLE patients with active disease in comparison to sera of healthy age matched controls. Further, some of the differential expressed spots were characterised [...]

Autoantibody profiling to follow evolution of lupus syndromes

2016-10-16T12:02:13+01:00 2012-12-1|Categories: Divulgação|Tags: , , |

Introduction: Identification of patients who are in early stages of lupus is currently done through clinical evaluation and is not greatly facilitated by available diagnostic tests. Profiling for patient characteristics and antibody specificities that predict disease would enhance the ability of physicians to identify and treat early cases prior to onset of organ damaging illness. Methods: A group [...]

B lymphocyte-typing for prediction of clinical response to rituximab

2016-07-09T08:40:43+01:00 2012-12-1|Categories: Divulgação|Tags: , |

Introduction: The prediction of therapeutic response to rituximab in rheumatoid arthritis is desirable. We evaluated whether analysis of B lymphocyte subsets by flow cytometry would be useful to identify non-responders to rituximab ahead of time. Methods: Fifty-two patients with active rheumatoid arthritis despite therapy with TNF-inhibitors were included in the national rituximab registry. DAS28 was determined before and [...]

Inflammation associated anemia and ferritin as disease markers in SLE

2016-07-09T08:39:28+01:00 2012-12-1|Categories: Divulgação|Tags: , , , |

Introduction: In a recent screening to detect biomarkers in systemic lupus erythematosus (SLE), expression of the iron storage protein, ferritin, was increased. Given that proteins that regulate the storage, transfer and release of iron play an important role in inflammation, this study aims to determine the serum and urine levels of ferritin and of the iron transfer protein, transferrin, [...]

House Bill 6218 would create interdepartmental autoimmune disease coordinating committee

2016-10-16T12:02:14+01:00 2012-8-21|Categories: Divulgação|

Autoimmune disease patients received a win recently when U.S. Rep. Ann Marie Buerkle (R-NY) introduced House Bill 6218 to Congress. The bill would create an interdepartmental autoimmune disease coordinating committee. The governmental agency committee would include the Assistant Secretary of Health, the Commissioner of Food and Drugs and the Director of the National Institutes of Health [...]