Arthritis / Rheumatology News From Medical News Today Scientists at UCSF have discovered an abnormality in a patient's immune system that may lead to safer therapies for autoimmune diseases such as rheumatoid arthritis and colitis, as well as potential new ways to treat transplant rejection. The research identified antibodies from a woman's immune system that prevent [...]
Hachulla, E., Carpentier, P., Gressin, V., Diot, E., Allanore, Y., Sibilia, J., Launay, D., Mouthon, L., Jego, P., Cabane, J., de Groote, P., Chabrol, A., Lazareth, I., Guillevin, L., Clerson, P., Humbert, M., the ItinerAIR-Sclerodermie Study Investigator Objectives. This longitudinal study investigated survival, risk factors and causes of death in the multicentre ItinérAIR-Sclérodermie cohort of patients with [...]
James Wentworth & Clare Davies Abstract Systemic lupus erythematosus (SLE) is a complex, chronic, autoimmune disorder that involves multiple organ systems including the skin, joints, heart, lungs, blood, kidneys and, in the most severe cases, the brain. The disease mainly affects women from Afro-Caribbean, Asian or Hispanic descent; Caucasians are affected to a lesser extent. Ver artigo [...]
Arthritis / Rheumatology News From Medical News Today Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that surveyed rheumatologists say that a therapy's effect on reducing the signs and symptoms of rheumatoid arthritis at one year is the attribute that most influences their prescribing decisions in treating [...]
John Kirwan Abstract Although low-dose glucocorticoids, in conjunction with DMARDs, are known to halt or severely retard the erosive destruction of joints in patients with early rheumatoid arthritis (RA), the potential adverse effects of low-dose glucocorticoids and the benefit:risk ratio of treatment are a concern for many clinicians. Malysheva and colleagues undertook a retrospective, open-label review [...]
Abstract Original article Genovese MC et al. (2008) Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis. A phase I/II randomized, blinded, placebo-controlled, dose-ranging study. Arthritis Rheum 58: 2652–2661 PubMed Ver artigo completo
Original article Giles JT et al. (2008) Association of body composition with disability in rheumatoid arthritis: impact of appendicular fat and lean tissue mass. Arthritis Rheum 15: 1407–1415 Article Increased body fat mass and decreased lean body mass are independently correlated with impaired physical function in patients with rheumatoid arthritis (RA); body fat mass and lean mass in the [...]
Josef S Smolen and Daniel Aletaha The changes occurring in the field of rheumatoid arthritis (RA) over the past decade or two have encompassed new therapies and in particular also a new look at the clinical characteristics of the disease in the context of therapeutic improvements. It has been shown that composite disease activity indices have [...]
Kaiser, R, Cleveland, C M, Criswell, L A Annals of the Rheumatic Diseases current issue Objectives: Few studies have examined thrombosis in systemic lupus erythematosus (SLE), none have included Asian-Americans, and most have had small sample sizes. We analysed risk factors for thrombosis in a large, multi-ethnic SLE cohort. Methods: We studied 1930 SLE subjects, including Caucasians, African-Americans, [...]
Nature Clinical Practice Rheumatology 4, 346 (2008). Author: Boulos Haraoui Ver artigo completo