Intensified COBRA therapy induces remission in 90% of patients with early RA
Nature Clinical Practice Rheumatology 4, 564 (2008). Ver artigo completo
Imunoglobulina intravenosa e Síndrome de Sjogren
Resumo A síndrome de Sjögren (SS) é uma patologia auto-imune com incidência e prevalência importantes, manifestações clínicas variadas e critérios diagnósticos bem definidos. Áreas como os seus mecanismos fisiopatológicos e novas estratégias terapêuticas têm merecido atenção crescente. A imunoglobulina intravenosa (IgIV) está indicada para o tratamento de várias entidades nosológicas, sendo crescente a investigação acerca dos seus mecanismos de acção, nomeadamente sobre a [...]
Treatment of rheumatoid arthritis: state of the art 2009
Publicado: quinta-feira, 1 de Outubro de 2009 21:30 Autor: Ronald F. van Vollenhoven Few, if any, areas of medical therapeutics have witnessed such dramatic changes as those that have occurred in the therapy of rheumatoid arthritis (RA) during the past two decades. Improvements in clinical trials methodologies, the introduction of no fewer than nine biologic agents with distinct [...]
Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial
Dr RF van Vollenhoven, S Ernestam, P Geborek, IF Petersson, L Cöster, E Waltbrand, A Zickert, J Theander, Å Thörner, H Hellström, A Teleman, C Dackhammar, F Akre, K Forslind, L Ljung, R Oding, A Chatzidionysiou, M Wörnert, J Bratt Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate [...]
Rheumatoid arthritis market
Jeffrey G. Stoll & Uma Yasothan Abstract Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that affects ~0.8% of the adult population worldwide. Ver artigo completo
Rheumatoid arthritis and smoking: putting the pieces together
Zsuzsanna Baka, Edit Buzás and György Nagy Abstract Besides atherosclerosis and lung cancer, smoking is considered to play a major role in the pathogenesis of autoimmune diseases. It has long been known that there is a connection between rheumatoid factor-positive rheumatoid arthritis and cigarette smoking. Recently, an important gene–environment interaction has been revealed; that is, carrying specific HLA-DRB1 alleles [...]
Pregnancy and Systemic Lupus Erythematosus: Review of Clinical Features and Outcome of 51 Pregnancies at a Single Institution
Graziela Carvalheiras & Pedro Vita & Susana Marta & Rita Trovão & Fátima Farinha & Jorge Braga & Guilherme Rocha & Isabel Almeida & António Marinho & Teresa Mendonça & Paulo Barbosa & João Correia & Carlos Vasconcelos Published online: 15 July 2009 # Humana Press Inc. 2009 Abstract Systemic lupus erythematosus (SLE) is mainly a disease of fertile [...]
Acidentes vasculares cerebrais de repeticao como manifestacao de arterite de celulas gigantes
Relapsing strokes as a manifestation of giant-cell arteritis Patrícia Luís, João Pereira, Lucília Carvalho, Alberto Mello e Silva, Pedro Abecasis Resumo A arterite de células gigantes é uma vasculite que atinge artérias de grande e médio calibre, preferencialmente a aorta e os seus ramos cranianos, o que explica alguns dos seus sintomas clássicos (amaurose, claudicação da [...]
Síndrome de Sweet e Doença Inflamatória Intestinal – uma associação pouco frequente
Sweet’s Syndrome and Inflammatory Bowel Disease – uncommon association Patricia Gonçalves, José Simão Miranda, J. A. Mascarenhas Araújo Resumo O Síndrome de Sweet (SSw) é uma dermatose neutrofílica caracterizada pela presença de febre, neutrofilia e lesões cutâneas cuja histologia revela um infiltrado inflamatório difuso neutrofílico da derme. A fisiopatologia deste Síndrome ainda não foi totalmente esclarecida. Pode [...]
HLA in Portuguese Systemic Lupus Erythematosus Patients and Their Relation to Clinical Features
Carlos Vasconcelos, Claudia Carvalho, Barbara Leal, Clara Pereira, Andreia Bettencourt, Paulo P. Costa, Antonio Marinho, Paulo Barbosa, Isabel Almeida, Fatima Farinha, Teresa Mendonça, Joao Araujo Correia, Denisa Mendonça and Berta Martins Systemic lupus errythematosus (SLE) is a clinically heterogeneous disease translating the different genetic and environmental factors involved. Polymorphisms at several loci, including the Major Histocompatibility Complex (MHC), have been associated worldwide with SLE, although inconsistencies exist among these [...]