Artrite Reumatóide

Jeffrey G. Stoll & Uma Yasothan Abstract Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that affects ~0.8% of the adult population worldwide. Ver artigo completo

Zsuzsanna Baka, Edit Buzás and György Nagy Abstract Besides atherosclerosis and lung cancer, smoking is considered to play a major role in the pathogenesis of autoimmune diseases. It has long been known that there is a connection between rheumatoid factor-positive rheumatoid arthritis and cigarette smoking. Recently, an important gene–environment interaction has been revealed; that is, carrying specific HLA-DRB1 alleles [...]

Joel M Kremer Abstract Weinblatt and colleagues have studied the efficacy and safety of etanercept 50 mg twice weekly in comparison with etanercept 50 mg once weekly in patients with longstanding rheumatoid arthritis. The study failed to demonstrate any clinically meaningful or statistically significant benefit of the use of the twice weekly dosage. There was also [...]