NEW YORK (Reuters Health) - Sifalimumab, an anti-interferon alpha monoclonal antibody, may lead to some improvement in patients with systemic lupus erythematosus (SLE), according to a new trial. In a paper online March 23 in Annals of the Rheumatic Diseases, Dr. Munther Khamashta of King's College London and colleagues note that treatment of SLE presents a [...]
Consensus document from the systemic auto-immune disease group (GEAS) of the Spanish Society of Internal Medicine (SEMI) and the Spanish Society of Nephrology (S.E.N.) Guillermo Ruiz-Irastorza, Gerard Espinosa, Miguel A. Frutos, Juan Jiménez-Alonso, Manuel Praga, Lucio Pallarés, Francisco Rivera, Ángel Robles-Marhuenda, Alfons Segarra, Carlos Quereda Lupus nephritis affects over half of all patients with systemic lupus erythematosus (SLE). This condition [...]
C Toworakul, N Kasitanon, W Sukitawut, R Wichinun and W Louthrenoo We performed this study to determine sensitivity and specificity of pleural effusion antinuclear antibodies (ANA) at a titer of 1 : 160, and the ratio of pleural effusion to serum ANA of 1, to distinguish between pleural fluid from lupus pleuritis and other causes. A prospective study of [...]
Catarina Dias and David A. Isenberg Abstract Autoimmune rheumatic diseases (ARD), such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and Sjögren’s syndrome (SS), have consistently been associated with the development of B-cell non-Hodgkin lymphoma (BCNHL). In this Review, we focus on reports published since 2006 and summarize the data regarding the BCNHL subtypes and clinical findings associated with [...]
Frédéric A Houssiau, David D’ Cruz, Shirish Sangle, Philippe Remy, Carlos Vasconcelos, Radmila Petrovic, Christoph Fiehn, Enrique de Ramon Garrido, Inge-Magrethe Gilboe, Maria Tektonidou, Daniel Blockmans, Isabelle Ravelingien, Véronique le Guern, Geneviève Depresseux, Loïc Guillevin, Ricard Cervera, the MAINTAIN Nephritis Trial Group ABSTRACT Background Long-term immunosuppressive treatment does not efficiently prevent relapses of lupus nephritis (LN). This investigator-initiated [...]
Arthritis Research & Therapy 2010, 12:R191 doi:10.1186/ar3161 Anna R Broder (abroder@montefiore.org) Jonathan N Tobin (JNTobin@CDNetwork.org) Chaim Putterman (chaim.putterman@einstein.yu.edu) Abstract: Introduction: We compared the odds of vitamin D deficiency in three chronic diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and type 2 diabetes (T2DM), adjusting for medications, demographics, and laboratory parameters, common to all three diseases. We also designed multivariate models [...]
James Wentworth & Clare Davies Abstract Systemic lupus erythematosus (SLE) is a complex, chronic, autoimmune disorder that involves multiple organ systems including the skin, joints, heart, lungs, blood, kidneys and, in the most severe cases, the brain. The disease mainly affects women from Afro-Caribbean, Asian or Hispanic descent; Caucasians are affected to a lesser extent. Ver artigo [...]
Graziela Carvalheiras & Pedro Vita & Susana Marta & Rita Trovão & Fátima Farinha & Jorge Braga & Guilherme Rocha & Isabel Almeida & António Marinho & Teresa Mendonça & Paulo Barbosa & João Correia & Carlos Vasconcelos Published online: 15 July 2009 # Humana Press Inc. 2009 Abstract Systemic lupus erythematosus (SLE) is mainly a disease of fertile [...]
Carlos Vasconcelos, Claudia Carvalho, Barbara Leal, Clara Pereira, Andreia Bettencourt, Paulo P. Costa, Antonio Marinho, Paulo Barbosa, Isabel Almeida, Fatima Farinha, Teresa Mendonça, Joao Araujo Correia, Denisa Mendonça and Berta Martins Systemic lupus errythematosus (SLE) is a clinically heterogeneous disease translating the different genetic and environmental factors involved. Polymorphisms at several loci, including the Major Histocompatibility Complex (MHC), have been associated worldwide with SLE, although inconsistencies exist among these [...]