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Artrite Reumatóide

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Palindromic Rheumatism With Positive Anticitrullinated Peptide/Protein Antibodies Is Not Synonymous With Rheumatoid Arthritis. A Longterm Followup Study

2016-10-16T12:02:13+01:00 2013-1-3|Categories: Artrite Reumatóide|

Palindromic rheumatism (PR) is usually defined as an inflammatory arthritis (IA), typically involving only a few joints and resolving over a short period of time. Multiple studies have shown that a proportion of patients with PR may develop persistent IA that can later develop into persistent disease classified as rheumatoid arthritis (RA; most common), systemic lupus [...]

Safety and efficacy of ARA290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double blind, pilot study.

2016-07-13T08:44:10+01:00 2013-1-3|Categories: Artrite Reumatóide|

Lara Heij, Marieke Niesters, Maarten Swartjes, Elske Hoitsma, Marjolein Drent, Ann Dunne, Jan C. Grutters, Oscar Vogels, Michael Brines, Anthony Cerami, Albert Dahan ABSTRACT ARA290, a peptide designed to activate the innate repair receptor that arrests injury and initiates cytoprotection, anti‐inflammation, and healing, reduces allodynia in preclinical neuropathy models. We studied the safety and efficacy of ARA 290 to [...]

Can Flare Be Predicted in DMARD Treated RA Patients in Remission, and Is It Important?

2016-07-13T08:48:48+01:00 2012-8-29|Categories: Artrite Reumatóide|

Abstract Objectives The treatment target for patients with rheumatoid arthritis (RA) is remission. Imaging techniques and remission criteria may identify patients at risk of flare and associated consequences. This study aimed to determine the clinical, functional and imaging associations of disease flare in patients with RA in remission and any effect on long-term outcomes. Methods RA patients in [...]

The effect of smoking or alcohol consumption on markers of systemic inflammation, immunoglobulin levels and immune response following pneumococcal vaccination in patients with arthritis

2016-07-13T08:50:04+01:00 2012-7-24|Categories: Artrite Reumatóide|

Carmen Roseman (carmen.roseman@skane.se}) Lennart Truedsson (lennart.truedsson@skane.se}) Meliha C Kapetanovic (meliha.c_kapetanovic@med.lu.se}) Abstract Introduction To study influence of cigarette smoking and alcohol consumption on immune response to heptavalent pneumococcal conjugate vaccine, immunoglobulin levels (Ig) and markers of systemic inflammation in patients with rheumatoid arthritis (RA) or spondylarthropathy (SpA). Methods In total, 505 patients were vaccinated. Six prespecified groups were enrolled: RA on MTX treatment [...]

The Pathogenesis of Rheumatoid Arthritis

2016-10-16T12:02:14+01:00 2011-12-8|Categories: Artrite Reumatóide|

Rheumatoid arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications, early death, and socioeconomic costs.1 The cause of rheumatoid arthritis is unknown, and the prognosis is guarded. However, advances in understanding the pathogenesis of the disease have fostered the development of new therapeutics, with improved outcomes. The current treatment strategy, which reflects this progress, is to initiate [...]

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

2016-07-13T08:52:01+01:00 2011-12-8|Categories: Artrite Reumatóide|

Nan Hu, Johanna Westra, Abraham Rutgers, Berber Doornbos-Van der Meer, Minke G Huitema, Coen A Stegeman, Wayel H Abdulahad, Simon C Satchell, Peter W Mathieson, Peter Heeringa and Cees G M Kallenberg Abstract Introduction: In anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV), persistent inflammation within the vessel wall suggests perturbed neutrophil trafficking leading to accumulation of activated neutrophils in the microvascular compartment. [...]

Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study

2016-07-13T08:53:52+01:00 2011-11-7|Categories: Artrite Reumatóide|Tags: , , , , , |

Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi and Sicco A Scherjon Abstract Introduction: Studies have shown that fetal progenitor cells persist in maternal blood or bone marrow for more than 30 years after delivery. Increased trafficking of fetal cells occurs during pregnancy complications, such [...]