Núcleo de Estudos de Doenças Auto-imunes

Sociedade Portuguesa de Medicina Interna
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So far marco.marques has created 232 blog entries.

B lymphocyte-typing for prediction of clinical response to rituximab

2016-07-09T08:40:43+01:00 2012-12-1|Categories: Divulgação|Tags: , |

Introduction: The prediction of therapeutic response to rituximab in rheumatoid arthritis is desirable. We evaluated whether analysis of B lymphocyte subsets by flow cytometry would be useful to identify non-responders to rituximab ahead of time. Methods: Fifty-two patients with active rheumatoid arthritis despite therapy with TNF-inhibitors were included in the national rituximab registry. DAS28 was determined before and [...]

Inflammation associated anemia and ferritin as disease markers in SLE

2016-07-09T08:39:28+01:00 2012-12-1|Categories: Divulgação|Tags: , , , |

Introduction: In a recent screening to detect biomarkers in systemic lupus erythematosus (SLE), expression of the iron storage protein, ferritin, was increased. Given that proteins that regulate the storage, transfer and release of iron play an important role in inflammation, this study aims to determine the serum and urine levels of ferritin and of the iron transfer protein, transferrin, [...]

Can Flare Be Predicted in DMARD Treated RA Patients in Remission, and Is It Important?

2016-07-13T08:48:48+01:00 2012-8-29|Categories: Artrite Reumatóide|

Abstract Objectives The treatment target for patients with rheumatoid arthritis (RA) is remission. Imaging techniques and remission criteria may identify patients at risk of flare and associated consequences. This study aimed to determine the clinical, functional and imaging associations of disease flare in patients with RA in remission and any effect on long-term outcomes. Methods RA patients in [...]

House Bill 6218 would create interdepartmental autoimmune disease coordinating committee

2016-10-16T12:02:14+01:00 2012-8-21|Categories: Divulgação|

Autoimmune disease patients received a win recently when U.S. Rep. Ann Marie Buerkle (R-NY) introduced House Bill 6218 to Congress. The bill would create an interdepartmental autoimmune disease coordinating committee. The governmental agency committee would include the Assistant Secretary of Health, the Commissioner of Food and Drugs and the Director of the National Institutes of Health [...]

Early systemic sclerosis: short-term disease evolution and factors predicting the development of new manifestations of organ involvement

2016-10-16T12:02:14+01:00 2012-8-17|Categories: Divulgação|Tags: , , |

Introduction. We investigated early Systemic Sclerosis (SSc) (i.e. Raynaud’s phenomenon with SSc marker autoantibodies and/or typical capillaroscopic findings and no manifestations other than puffy fingers or arthritis) versus Undifferentiated Connective Tissue Disease (UCTD) to identify predictors of short-term disease evolution. Methods. Thirty-nine early SSc and 37 UCTD patients were investigated. At baseline, all patients underwent clinical evaluation, B-mode echocardiography, lung [...]

The effect of smoking or alcohol consumption on markers of systemic inflammation, immunoglobulin levels and immune response following pneumococcal vaccination in patients with arthritis

2016-07-13T08:50:04+01:00 2012-7-24|Categories: Artrite Reumatóide|

Carmen Roseman (carmen.roseman@skane.se}) Lennart Truedsson (lennart.truedsson@skane.se}) Meliha C Kapetanovic (meliha.c_kapetanovic@med.lu.se}) Abstract Introduction To study influence of cigarette smoking and alcohol consumption on immune response to heptavalent pneumococcal conjugate vaccine, immunoglobulin levels (Ig) and markers of systemic inflammation in patients with rheumatoid arthritis (RA) or spondylarthropathy (SpA). Methods In total, 505 patients were vaccinated. Six prespecified groups were enrolled: RA on MTX treatment [...]

Molécula contra a artrite reumatóide criada em Portugal vai ser testada na China

2016-10-16T12:02:14+01:00 2012-6-11|Categories: Nacionais|

Uma empresa de biotecnologia portuguesa estabeleceu um acordo com um instituto de investigação chinês para se realizarem na China ensaios clínicos de uma molécula contra a artrite reumatóide. O acordo entre a TechnoPhage, a empresa portuguesa, e o Instituto de Matéria Médica de Xangai foi apresentado esta segunda-feira em Lisboa. A artrite reumatóide é uma doença [...]

Doenças autoimunes: 50 mil consultas foram realizadas no ano passado

2016-10-16T12:02:14+01:00 2012-4-17|Categories: Nacionais|

Dados do Núcleo de Estudos de Doenças Autoimunes No ano passado realizaram-se 50 mil consultas a portadores de doenças autoimunes, nos 40 centros do Núcleo de Estudos de Doenças Autoimunes (NEDAI) da Sociedade Portuguesa de Medicina Interna. De acordo com os dados divulgados no âmbito da 18.ª Reunião Anual do NEDAI, aos quais a agência Lusa [...]