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Diagnosis and treatment of lupus nephritis

marco.marques 2016-10-16T12:02:14+01:00 2012-1-1|Categories: Lúpus Sistémico Eritematoso|

Consensus document from the systemic auto-immune disease group (GEAS) of the Spanish Society of Internal Medicine (SEMI) and the Spanish Society of Nephrology (S.E.N.) Guillermo Ruiz-Irastorza, Gerard Espinosa, Miguel A. Frutos, Juan Jiménez-Alonso, Manuel Praga, Lucio Pallarés, Francisco Rivera, Ángel Robles-Marhuenda, Alfons Segarra, Carlos Quereda Lupus nephritis affects over half of all patients with systemic lupus erythematosus (SLE). This condition [...]

The Pathogenesis of Rheumatoid Arthritis

marco.marques 2016-10-16T12:02:14+01:00 2011-12-8|Categories: Artrite Reumatóide|

Rheumatoid arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications, early death, and socioeconomic costs.1 The cause of rheumatoid arthritis is unknown, and the prognosis is guarded. However, advances in understanding the pathogenesis of the disease have fostered the development of new therapeutics, with improved outcomes. The current treatment strategy, which reflects this progress, is to initiate [...]

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

marco.marques 2016-07-13T08:52:01+01:00 2011-12-8|Categories: Artrite Reumatóide|

Nan Hu, Johanna Westra, Abraham Rutgers, Berber Doornbos-Van der Meer, Minke G Huitema, Coen A Stegeman, Wayel H Abdulahad, Simon C Satchell, Peter W Mathieson, Peter Heeringa and Cees G M Kallenberg Abstract Introduction: In anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV), persistent inflammation within the vessel wall suggests perturbed neutrophil trafficking leading to accumulation of activated neutrophils in the microvascular compartment. [...]

Rates of, and risk factors for, severe infections in patients with systemic autoimmune diseases receiving biological agents off-label

marco.marques 2016-10-16T12:02:14+01:00 2011-12-1|Categories: Divulgação|Tags: adalimumab, etanercept, Infection rate, infliximab, rituximab, Sjögren syndrome, systemic lupus erythematosus, vasculitis|

Introduction: The purpose of this observational study was to analyze the rates, characteristics and associated risk factors of severe infections in patients with systemic autoimmune diseases (SAD) who were treated off-label with biological agents in daily practice. Methods: The BIOGEAS registry is an ongoing Spanish prospective cohort study investigating the long-term safety and efficacy of the off-label use of [...]

Síndrome de Churg-Strauss

marco.marques 2016-07-09T09:31:19+01:00 2011-11-27|Categories: Artigos Originais e de Revisão|Tags: ANCA, síndrome de Churg-Strauss, vasculite|

Churg-Strauss Syndrome BF Rodrigues, JM Araújo Resumo A síndrome de Churg-Strauss é uma vasculite ANCA-associada de pequenos e médios vasos. As manifestações clínicas mais comuns são eosinofilia marcada, asma, sinusite crónica, infiltrados pulmonares, cardiomiopatia, queixas gastrointestinais e mononeurite multiplex. Os anticorpos Anti-MPO (anti-mieloperoxidade), pANCA (com padrão de imunoflurescência perinuclear) encontram-se presentes em 38-59% dos casos. O envolvimento cardíaco é uma importante causa [...]

Increased incidence of pregnancy complications in women who later develop scleroderma: a case control study

marco.marques 2016-07-13T08:53:52+01:00 2011-11-7|Categories: Artrite Reumatóide|Tags: Chimerism, Hypertension, Intra-uterine growth restriction, Pre-eclampsia, pregnancy, Systemic Sclerosis|

Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi and Sicco A Scherjon Abstract Introduction: Studies have shown that fetal progenitor cells persist in maternal blood or bone marrow for more than 30 years after delivery. Increased trafficking of fetal cells occurs during pregnancy complications, such [...]

Genomics and the Multifactorial Nature of Human Autoimmune Disease

marco.marques 2016-07-09T09:32:27+01:00 2011-10-27|Categories: Artigos Originais e de Revisão|

Judy H. Cho, M.D., and Peter K. Gregersen, M.D. The major autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, type 1 diabetes mellitus, psoriasis, and inflammatory bowel disease, share epidemiologic, clinical, and therapeutic features. In each of these diseases, chronic and often intermittent inflammation contributes over time to the destruction of target organs that house inciting antigens or are [...]

European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies

marco.marques 2016-10-16T12:02:14+01:00 2011-10-25|Categories: Nacionais|

Psoriatic arthritis (PsA) is a clinically heterogeneous disease. Clear consensual treatment guidance focused on the musculoskeletal manifestations of PsA would be advantageous. The authors present European League Against Rheumatism (EULAR) recommendations for the treatment of PsA with systemic or local (non-topical) symptomatic and disease-modifying antirheumatic drugs (DMARD). Full document here.

Golimumab, a New Human Tumor Necrosis Factor Antibody, Administered Every Four Weeks as a Subcutaneous Injection in Psoriatic Arthritis

marco.marques 2016-07-09T09:25:07+01:00 2011-10-25|Categories: Artrite Psoriática|

Twenty-Four–Week Efficacy and Safety Results of a Randomized, Placebo-Controlled Study Arthur Kavanaugh, Iain McInnes, Philip Mease, Gerald G. Krueger, Dafna Gladman, Juan Gomez-Reino, Kim Papp, Julie Zrubek, Surekha Mudivarthy, Michael Mack, Sudha Visvanathan, and Anna Beutler Methods. Adult patients with PsA who had at least 3 swollen and 3 tender joints and active psoriasis were randomly assigned to receive subcutaneous injections of placebo (n 113), golimumab 50 mg (n [...]

Investigação genética aponta para um novo tratamento para a asma

marco.marques 2016-10-16T12:02:14+01:00 2011-9-9|Categories: Nacionais|

Manuel Ferreira, investigador português na Austrália, liderou o estudo que associou duas variantes genéticas ao aumento de risco de asma e que foi publicado quinta-feira na revista The Lancet A equipa de investigadores do Queensland Institute of Medical Research (QIMR), na Austrália, comparou centenas de ADN de doentes asmáticos e pessoas saudáveis e encontrou diferenças. Foram [...]

Núcleo de Estudos de Doenças Auto-imunes

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