Núcleo de Estudos de Doenças Auto-imunes

Sociedade Portuguesa de Medicina Interna
T: (+351) 217 520 570 / Email: info@nedai.org


Developments in the clinical understanding of rheumatoid arthritis

2016-10-16T12:02:17+01:00 2009-10-27|Categories: Arquivo|

Josef S Smolen and Daniel Aletaha The changes occurring in the field of rheumatoid arthritis (RA) over the past decade or two have encompassed new therapies and in particular also a new look at the clinical characteristics of the disease in the context of therapeutic improvements. It has been shown that composite disease activity indices have [...]

Risk and protective factors for thrombosis in systemic lupus erythematosus: results from a large, multi-ethnic cohort

2016-07-13T20:11:48+01:00 2009-10-27|Categories: Arquivo|

Kaiser, R, Cleveland, C M, Criswell, L A Annals of the Rheumatic Diseases current issue Objectives: Few studies have examined thrombosis in systemic lupus erythematosus (SLE), none have included Asian-Americans, and most have had small sample sizes. We analysed risk factors for thrombosis in a large, multi-ethnic SLE cohort. Methods: We studied 1930 SLE subjects, including Caucasians, African-Americans, [...]

Discovery Of Process Found To Play Role In Rheumatoid Arthritis Could Lead To New Treatment

2016-07-13T20:10:26+01:00 2009-10-27|Categories: Arquivo|

Arthritis / Rheumatology News From Medical News Today Although the origin of rheumatoid arthritis (RA) remains unclear, bioactive proteins known as cytokines, particularly TNFα and IL-6, which are involved in inflammation, play a major role in the disease by contributing to joint and tissue destruction. Placenta growth factor (PIGF), another cytokine, has been thought to be [...]

How regulatory T cells work

2016-07-13T20:07:50+01:00 2009-10-27|Categories: Arquivo|

Nature Reviews Immunology 8, 523 (2008). Authors: Dario A. A. Vignali, Lauren W. Collison & Creg J. Workman Regulatory T (TReg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilizing immunity and limiting antitumour immunity. Given that TReg cells can have [...]