Artrite Reumatóide

Consequences for Response Prediction to Rituximab Tamarah D de Jong; Saskia Vosslamber; Marjolein Blits; Gertjan Wolbink; Mike T Nurmohamed; Conny J van der Laken; Gerrit Jansen; Alexandre E Voskuyl; Cornelis L Verweij Abstract Introduction Elevated type I interferon (IFN) response gene (IRG) expression has proven clinical relevance in predicting rituximab non-response in rheumatoid arthritis (RA). Interference between [...]

Abstract Introduction: In vitro apoptosis of peripheral monocytes in rheumatoid arthritis (RA) is disturbed and influenced by cytokine production and transmembrane TNF (tmTNF) reverse signaling. The goal of the study was the analysis of the predictive value of the rate of in vitro apoptosis for the therapeutic response to anti-TNF treatment. Methods: Spontaneous and tmTNF reverse signaling-induced apoptosis [...]

Abstract Adipo(cyto)kines are mostly produced by adipose tissue and orchestrate the adverse impact of excess adiposity on cardiovascular risk. Adipokines also contribute importantly to the pathophysiology of rheumatoid arthritis. Congruent with data reported in previous investigations, Kang and colleagues report in this issue of Arthritis Research & Therapy that adipokine concentrations are further associated with metabolic risk and [...]

Abstract Anti-Th/To autoantibodies have been recognized as serological markers of systemic sclerosis (SSc) for more than 20 years. However, validated immunoassay kits to test this specifi city have not been commercially available. SSc autoantibodies are basically mutually exclusive and are associated with a certain subset of the disease and/or with organ involvement. Anti-Th/ To are generally considered to be markers of the limited cutaneous [...]

Medscape Medical News, 2013-06-24 MADRID, Spain — The European League Against Rheumatism (EULAR) guidelines, unveiled here at the 2013 congress, are being updated from 2010 and contain notable differences from the new American College of Rheumatology recommendations. The guidelines, which are not yet published, focus on the efficacy of conventional disease-modifying antirheumatic drugs (DMARDs) as first-line therapy, [...]

James R. O’Dell, M.D., Ted R. Mikuls, M.D., M.S.P.H., Thomas H. Taylor, M.D., Vandana Ahluwalia, M.D., Mary Brophy, M.D., M.P.H., Stuart R. Warren, J.D., Pharm.D., Robert A. Lew, Ph.D., Amy C. Cannella, M.D., Gary Kunkel, M.D., Ciaran S. Phibbs, Ph.D., Aslam H. Anis, Ph.D., Sarah Leatherman, M.A., and Edward Keystone, M.D., for the CSP 551 RACAT Investigators Background Few [...]

Introduction Without much doubt, the most significant development in rheumatoid arthritis (RA) therapeutics during the past year has been the advancement of the first small-molecular agent in many years, the Janus kinase (JAK) inhibitor tofacitinib (Xeljanz™), to clinical use in the United States. Use in Europe is probably around the corner. The identification and detailed description [...]

Findings of a Phase IIIb, Multinational, Prospective, Randomized Study Michael E. Weinblatt, Michael Schiff, Robert Valente, Désireé van der Heijde, Gustavo Citera, Cathy Zhao, Michael Maldonado, and Roy Fleischmann Objective. There is a need for comparative studies to provide evidence-based treatment guidance for biologic agents in rheumatoid arthritis (RA). Therefore, this study was undertaken as the first head-to-head comparison of subcutaneous (SC) abatacept and SC adalimumab, both [...]