Artrite Reumatóide

Palindromic rheumatism (PR) is usually defined as an inflammatory arthritis (IA), typically involving only a few joints and resolving over a short period of time. Multiple studies have shown that a proportion of patients with PR may develop persistent IA that can later develop into persistent disease classified as rheumatoid arthritis (RA; most common), systemic lupus [...]

Lara Heij, Marieke Niesters, Maarten Swartjes, Elske Hoitsma, Marjolein Drent, Ann Dunne, Jan C. Grutters, Oscar Vogels, Michael Brines, Anthony Cerami, Albert Dahan ABSTRACT ARA290, a peptide designed to activate the innate repair receptor that arrests injury and initiates cytoprotection, anti‐inflammation, and healing, reduces allodynia in preclinical neuropathy models. We studied the safety and efficacy of ARA 290 to [...]

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Journal of Clinical Rheumatology, 2012-12-01

Abstract Objectives The treatment target for patients with rheumatoid arthritis (RA) is remission. Imaging techniques and remission criteria may identify patients at risk of flare and associated consequences. This study aimed to determine the clinical, functional and imaging associations of disease flare in patients with RA in remission and any effect on long-term outcomes. Methods RA patients in [...]

News Author: Janis C. Kelly CME Author: Désirée Lie, MD, MSEd Faculty and Disclosures CME Released: 07/16/2012; Valid for credit through 07/16/2013 Consulte artigo

Carmen Roseman (carmen.roseman@skane.se}) Lennart Truedsson (lennart.truedsson@skane.se}) Meliha C Kapetanovic (meliha.c_kapetanovic@med.lu.se}) Abstract Introduction To study influence of cigarette smoking and alcohol consumption on immune response to heptavalent pneumococcal conjugate vaccine, immunoglobulin levels (Ig) and markers of systemic inflammation in patients with rheumatoid arthritis (RA) or spondylarthropathy (SpA). Methods In total, 505 patients were vaccinated. Six prespecified groups were enrolled: RA on MTX treatment [...]

Rheumatoid arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications, early death, and socioeconomic costs.1 The cause of rheumatoid arthritis is unknown, and the prognosis is guarded. However, advances in understanding the pathogenesis of the disease have fostered the development of new therapeutics, with improved outcomes. The current treatment strategy, which reflects this progress, is to initiate [...]

Nan Hu, Johanna Westra, Abraham Rutgers, Berber Doornbos-Van der Meer, Minke G Huitema, Coen A Stegeman, Wayel H Abdulahad, Simon C Satchell, Peter W Mathieson, Peter Heeringa and Cees G M Kallenberg Abstract Introduction: In anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV), persistent inflammation within the vessel wall suggests perturbed neutrophil trafficking leading to accumulation of activated neutrophils in the microvascular compartment. [...]