Nature Reviews Immunology 8, 523 (2008).
Authors: Dario A. A. Vignali, Lauren W. Collison & Creg J. Workman
Regulatory T (TReg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilizing immunity and limiting antitumour immunity. Given that TReg cells can have both beneficial and …